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Managing side effects at each dosage tier Side effects follow the dose

Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice

36 Mechanistically, GSH can be converted into oxidized glutathione (GSSG) under the catalysis of glutathione peroxidase (GPx), at the same time H 2 O 2 is able to transfer into non-toxic H 2 O, then GSSG will be reduced to reform GSH again by glutathione reductase to maintain a cycle

To evaluate whether the nanoparticles would still display redox responsive MR switchable properties after addition of biologically relevant concentrations of reducing agents, MnO 2 /[email protected] (Mn = 1 mM) NPs were treated with different concentrations of GSH at pH = 7.4 and imaged under 3.0 T MR

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