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The senolytic effects varied between inducers and cell lines, but we identified 38 fragments (with diverse warheads, including chloroacetamides, cyanoacrylamides, acrylamides, aldehydes or sulfonyl fluorides) that selectively killed senescent cells in at least one of the three senescent conditions analysed (Fig

10.1080/14786419.2021.1969567 144 TanakaM.KajiK.NishimuraN.AsadaS.KoizumiA.MatsudaT.et al (2024)

Glutathione is a naturally occurring antioxidant that can be infused in high doses

However, important population gaps exist in the published safety data

Roten AT, Baker NL, Gray KM

The activation of TLR4 in monocytes and granulocytes induces a rapid rise in intracellular zinc levels