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In this setting, alternative routes of cobalamin administration have been developed, experimented and used with good effect such as the oral [3,10,13] and nasal [14,15]
Targeting microcirculation dysfunction NO plays an important role in maintaining an adequate blood supply for hepatic microvessels by affecting the expression of leukocytes, platelets, and endothelial cell adhesion molecules

Generally well-tolerated at standard doses

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Subjective changes: pain, range of motion, skin appearance, and any unusual symptoms

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