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Description
Asthenia, tiredness, and muscle weakness appear even without apparent anemia
The animal data backs this up in a striking way: a single dose lowered serotonin production in the brain, while long-term use raised it

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Your doctor usually diagnoses B12-deficiency anemia in conjunction with abnormal blood testing results

doi: 10.1371/journal.pone.0032296
NPs should take a proactive approach to prevent it by monitoring vitamin B12 or MMA concentrations during long-term metformin treatment and prescribing replacement therapy when low levels of B12 or increased levels of MMA are found
