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In lung cancer, M-MDSCs and MDSCs PMN-MDSCs activate different STAT pathways, with M-MDSCs upregulating STAT1 [94] and STAT3 signaling to induce CSC phenotypes and promote lung metastasis [95]

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Regulatory B cells (Bregs), particularly IL-10producing B10 cells, are decreased or functionally impaired in HT, diminishing control over pro-inflammatory T cell activity (Stafford, EA