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Although LNK has been shown to be expressed in a range of tissue including muscle, brain, testis, and hematopoietic cells (153), its ability to regulate GHR signaling is currently not clear

Furthermore, our data indicate that neuronal GHS-R deletion regulates genes mediating central thermogenic activation in ventromedial hypothalamus (VMH), paraventricular nucleus (PVN) and lateral hypothalamus (LH), implying elevated sympathetic outflow to brown adipose tissue and beige subcutaneous adipose tissues 9

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[Google Scholar] 19.Rowland A., Miners J.O., Mackenzie P.I