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Using preclinical models, we characterized interactions between GPX4, PC, and oxidative stress in TNBC cells, and established effects of GPX4 suppression on TNBC progression

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A clinician may then ask whether it is prudent to consider therapies that activate Nrf2 in the context of a cancer diagnosis

Based on the conservative sequence of Nrf2, Nrf2 can be divided into six structural-functional domains, named Neh1-Neh6 ( Figure 1 Kelch-like ECH-related protein-1 (Keap1) is a specific receptor for Nrf2 and the first major inhibitor of Nrf2, mainly present in the cytoplasm

Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis

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