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To determine CI activity, MAS plus alamethicin (2.5 g ml 1 ) and cytochrome c (10 g ml 1 ) were added to the mitochondria followed by 5 mM pyruvate + 5 mM malate + 1 mM NADH at port A, 2 M rotenone + 4 M antimycin A at port B, 0.5 mM TMPD + 1 mM ascorbic acid at port C and 50 mM azide at port D

Understanding these mechanisms provides the foundation for exploring therapeutic interventions that might support cellular health throughout the aging process

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It optimizes the health of the nervous system

They remain prescription therapeutics used under physician supervision, with proper dosing and ongoing monitoring