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Recommended endpoints: histology, functional assays, angiogenic markers (CD31, VEGF), and blinded scoring to reduce bias

The role of HGF/Met signaling in proliferation, metastasis, and angiogenesis has been investigated in HNSCC, leading to clinical trials with various Met inhibitors and HGF antibodies

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Vomiting, diarrhea, constipation, reflux-like discomfort, and abdominal cramping can also occur
