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Modules correlated with the KO genotype were enriched for neuronal and synaptic genes involved in vesicle-mediated transport, neurotransmitter secretion, and GTPase activity, suggesting that RAMP deletion disrupts synaptic signaling networks critical for metabolic regulation [2]

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Information source: www.mdpi.com/journal/molecules

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[11] The peptides effects on the nitric oxide system contribute to vascular protection in research models

the synergy is plausible and clinically observed, but not yet formally proven