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Some scientists believe that low carnitine levels in the blood could cause depression and fatigue, possibly even due to the use of medications

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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11

FIGURE 3 3.2.1 -L-glutamyl-4-nitroanilide (GPNA) GPNA, a glutamine analog synthesized by Esslinger, has been widely used to inhibit the glutamine transporter ASCT2 ( in vitro and in vivo (Ma et al., 2021)

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