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Synthesis and Biological Evaluation of Pyrazolo[3,4-B]Pyridine-3-Yl Pyrimidine Derivatives as sGC Stimulators for the Treatment of Pulmonary Hypertension

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Macrophages bind nascent HDL, that contain primarily apoA-I, through interaction with the ATP-binding cassette transport protein A1 (ABCA1)

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Environmental factors, genetic predisposition, and smoking are significant contributors to the development of RA ( In recent decades, the incidence of RA has increased significantly, and this trend is expected to continue ( This chronic condition is characterized by inflammation of the synovial membrane, leading to joint damage, swelling, stiffness, pain, tissue degradation, deformity, and instability