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On one hand, M1 macrophage-derived cytokines such as IL-6 and TNF- stimulate osteoclast differentiation and activation, promoting bone resorption (Meng et al., 2021)

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A key component believed to enhance these pharmacological effects is 1,2,3,4,6-penta- O -galloyl-glucopyranose, which plays a significant role in the plants bioactivity (Vargas-Ruiz et al., 2023)