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While the principles of N-terminal acetylation and C-terminal amidation are well established in peptide chemistry, direct comparative studies evaluating the modified forms biological activity against the parent peptide have not yet been published

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Maridebart/cafraglutide (MariTide), an Antibody-peptide Conjugate Molecule Maridebart/cafraglutide, or AMG 133, is a bispecific molecule that was created by conjugating two GLP- 1 analogue agonist peptides with a fully human monoclonal anti-human GIP receptor antagonist using amino acid linkers [124]

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Aug 14: In what is expected to become a multibillion-dollar blockbuster, Pfizers BCMAxCD3 bispecific antibody Elrexfio (elranatamab-bcmm) has secured an FDA accelerated approval as another off-the-shelf treatment option for patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior lines of therapy

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Interestingly, direct fibroblast proliferation as measured by cell assay was not significantly affected, suggesting the mechanism is more nuanced than simple cell replication

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