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DARs (DNA reachable regions) are genomic regions that exhibit a more open chromatin structure, where histone modifications play a pivotal role in facilitating the binding of transcription factors and other regulatory proteins to DNA, thereby regulating gene expression

Since ATF4 is known to work upstream of FGF21 as an early ISR effector, we also studied the metabolic phenotype of BAT-specific dual ATF4/PDSS2 knockout animals (DKO ATF4 ) (Appendix Fig

Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain

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Effect of alpha-linolenic acid supplementation on cardiovascular disease risk profile in individuals with obesity or overweight: a systematic review and meta-analysis of randomized controlled trials