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Description
Others have side effects that are so bad they aren't worth considering

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Importantly, there is functional crosstalk between NO signaling and TRPV1 activation: NO can modulate TRPV1 activity indirectly through protein kinase pathways, while TRPV1-driven calcium influx influences downstream NO production [91,92]

All of the experiments were approved by the local ethics committee

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The regulatory status varies by country and jurisdiction
