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Resulted transient burst of OXPHOS activity in turn promotes glycolysis and the metabolic shift ( 4.2 Upregulation of glycolysis Upregulation of proteins involved in glycolysis occurs early and is maintained throughout the reprogramming process up until the generation of established iPSCs ( Glycolysis is not only favored by upregulation of the glycolytic enzymes, but also by post-transcriptional regulation of other key metabolic enzymes

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