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So when the barrier becomes more permeable, the proposed mechanism is straightforward: substances that should stay in the gut lumen bacterial fragments, undigested food particles, pathogens cross into deeper tissue and the bloodstream, where they can drive immune activation and an increased antigenic and toxic load

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The flow of urine to the bladder, produced by the kidneys, is enabled thanks to the action of the ureter

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J Endocr Soc (2020) 4(9):bvaa075