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This glucose-lowering effect was comparable to that of metformin hydrochloridethe king glucose-lowering drug (Zubaidah et al., 2019)
[PubMed] [Google Scholar] 60.Godwin AK, Meister A, ODwyer PJ, Huang CS, Hamilton TC, Anderson ME

Abstract Zhi-zi-chi Decoction (ZZCD), composed of Fructus Gardeniae (Zhizi in Chinese, ZZ in brief) and Semen sojae praeparatum (Dandouchi in Chinese, DDC in brief), has been used as a drug therapy for depression for thousands of years in China

Metabolism 57, 10711077

Combining RNA interference with hyaluronan-coated nanoparticles offers a promising strategy for treating glaucoma ( 2.1.7 Adenosine Adenosine is a ubiquitous local modulator that interacts with four membrane receptors: A1, A2A, A2B, and A3 to regulate various physiological and pathological processes ( Activation of A1 receptors in the ciliary body and TM reduces AH production and outflow resistance, lowering IOP ( Adenosine receptor signaling pathways involve molecular mechanisms such as adenylyl cyclase, phospholipase-inositol triphosphate-diacylglycerol, and phosphatidylinositol-3-kinase, which activate MAPK pathways that influence gene transcription ( Several clinical studies, including Phase 2 and 3 trials, have focused on evaluating the efficacy of various topical formulations in lowering IOP in adults with OHT or POAG, comparing them to existing therapies like latanoprost and timolol (NCT01917383, NCT02565173)
doi:10.1017/jns.2019.28
