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doi: 10.1126/science.505013 157 JaureguiC.Blanco-LuquinI.MacasM.RoldanM.CaballeroC.PagolaI.et al

The side effects might be either due to high dose of vitamin B12 or allergic reaction to its composition

Doses of pyridoxine as low as 5-10 mg can antagonize levodopas effect if carbidopa is not present, so caution is warranted and any supplemental B beyond the nutritional dose should be under medical guidance

Noteworthy, as described above, there are significant time-varying arterio-venous differences in BAC (99), but the sampling of arterial, in contrast to venous blood, is challenging and poses an increased risk to study participants

The incorporation of SNCDs not only enables real-time tracking through fluorescence imaging but also maintains desirable nanoscale properties, such as narrow size distribution and good dispersibility