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adapts to ketone bodies during prolonged fasting Muscle : Uses both glucose and fatty acids depending on activity and availability Adipose tissue : Specialized for lipid storage and mobilization Liver : Central organ coordinating both lipid and carbohydrate metabolism This tissue-specific utilization emphasizes the complementary roles of the two pathways

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mitomiR-2392 , together with Ago2, was reported to recognize target sequences in the H-strand and partially inhibit polycistronic mtDNA transcription in a tongue squamous cell carcinoma (TSCC) cells, leading to downregulation of oxidative phosphorylation and upregulation of glycolysis (Fan et al., 2019)