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We thank the following funding organizations: NIH (R35CA209896 to BRS, 4R00CA166517 and 1R01GM122923 to SJD, R01CA171101 to FT, R01CA188025 to ST, CA102184 to MEM, HL114453, U19AI068021, NS076511, NS061817 to VEK and HB, R01GM115366, R01CA160417 to DT), JSPS KAKENHI (JP16K15257 and JP17H04064 to ST), ACS (RSG-16-014-01-CDD to DT), NNSFC (2016A030308011 and 31671435 to DT) and HFSP (RGP 0013/14) to MC and VEK