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For example, as a transcriptional coactivator, peroxisome proliferator-activated receptor coactivator 1 (PGC1) has been reported to be downregulated in TC cells, thereby inhibiting oxidative phosphorylation and inducing a glycolytic phenotype

doi:10.1016/j.ijantimicag.2007.04.006

Increasing clarithromycin resistance leads to reduce the eradication rate of clarithromycin-containing triple therapy, for example in Argentina cure rate is estimated at 75% [29]

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