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12: e0106

While NPs like salvianolic acid show preclinical antifibrotic activity, their undefined targets and pharmacokinetics hinder clinical adoptiona stark contrast to approved synthetics like pirfenidone (2,403 mg/day) (Noble et al., 2011) and nintedanib (300 mg/day) (Richeldi et al., 2014), which themselves face tolerability limitations (Raghu et al., 2022a)

Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR-alpha signaling

Salari, N
Today, non-surgical and regenerative therapies provide safer and often highly effective alternatives

Furthermore, urothelium from individuals with IC has demonstrated reduced cell proliferation and increased cell permeability (Fiehn and Kim, 2014)