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Cooking and processing also reduce the glutathione content in foods

Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and 2

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On the basis of the results available up to date, the Global Initiative for Chronic Obstructive Lung Disease [119] recognizes that mucolytic and antioxidant drugs, such as NAC, can be used as an adjunct therapy to reduce the risk of acute exacerbation of COPD, but in a limited way due to the lack of robust randomized controlled clinical trials (level of evidence B)

In the rat diabetes model, N-acetyl-cysteine and glutathione ethyl ester that are easily converted into GSH in vivo successfully suppressed the development of the cataract in early stages [184]

1 In particular, in the study of neurodegenerative diseases, cardiomyopathy, and rare genetic diseases, the predictive ability of traditional models is insufficient