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Consequently, the authors claim that the initiation of supplementation with high doses of antioxidant agents at the diagnosis of diabetes does not demonstrate the effectiveness of preserving beta cell function or metabolic balance

doi: 10.1016/j.pmedr.2018.02.007 77

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PGC-1, a pivotal regulator of mitochondrial biogenesis and cellular resistance to oxidative stress, plays a pivotal role in the function and survival of dopaminergic neurons in the substantia nigra (Halling and Pilegaard, 2020)