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As mentioned previously, increased cerebrovascular resistance at rest, whether it be related to aging or disease, is typically a negative change in cerebrovascular function and is a sign of greater flow impedanceultimately leading to reductions in CBF (Claassen et al., 2021)

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Its role in promoting tissue regeneration and enhancing nerve function can be beneficial for some individuals

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Other factors leading up the line are high blood pressure, different types of glomerulonephritis, diseases of the tissues within and in between the kidneys, bladder infections, and tumors