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To view a copy of this licence, visit About this article Cite this article Snchez-Castillo, A., Heylen, E., Hounjet, J

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The protective mechanisms include enhancing the nuclear translocation of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), upregulating the expression of Heme Oxygenase-1 (HO-1) following IR exposure, and increasing the expression levels of Glutathione Peroxidase 4 (GPX4) and Solute Carrier Family 7 Member 11 (SLC7A11) after radiotherapy (Xie et al., 2020)

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Genetic polymorphism and mutations of CYP genes including CYP1A1, CYP2A6, CYP2A13, CYP2C8/9/19, CYP2D6, CYP2B6 and CYP3A4 (37, 38) and the variations in the distribution of the common CYP gene allelic variants that are observed among several ethnic populations, such as Africans, White and African Americans, Asians, Caucasians and Europeans, are among the predominant factors determining to a great extent, the inter-individual and inter-ethnic deviations in drug response and adverse reactions (39, 40)