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(2019) Open trial of vitamin B12 nasal drops in adults with myalgic encephalomyelitis/chronic fatigue syndrome: comparison of responders and non-responders

It identifies the subset of patients who truly benefit from supplementation

The body requires time to replenish depleted stores, regenerate red blood cells, and repair neurological damage caused by prolonged deficiency

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If vitamin B12 treatment failed to alleviate the patients symptoms, the panelists agreed that doctors should consider alternative conditions that may explain the symptoms and should reevaluate the appropriateness of the dose of B12 therapy