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The increase in Hb oxidation during storage of RBCs may also be due to a decrease in their antioxidant capacity, resulting in the oxidation and deterioration of membrane lipids and proteins, which can ultimately lead to irreversible damage to the membrane

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Pharmacol Rev 52:113143, 2000

Pooled mitochondrial modulators have marginally outperformed placebo in improving, SDS scores ( p = 0.05