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doi: 10.1039/c7nr03272b
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Conversely, to reduce immunogenicity for repeated administrations, researchers suggest adjusting LNP compositions, using cleavable PEG variants or biodegradable polymers, and optimizing nanoparticle size and surface charge [397, 398]
High PDI can lead to inconsistent transfection efficiency, reduced stability, increased aggregation, and heightened immune recognition
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The potential role of vitamin D supplementation appeared promising in a few studies when given alone or in synergy with other co-interventions, largely driving immunomodulatory and antioxidant effects of vitamin D
