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Availability of data and materials All data used in this study are publicly available, with relevant citations detailed

For example, it helps in the conjugation of toxins, making them more water-soluble and easier to eliminate

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Long-term durability of AAV vector-induced gene expression and additional potential off-target effects are areas of ongoing research and development

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A recent study reported that nasal administration of TiO 2 -NPs (2.510 mg/Kg/90 days) to mice caused neuronal death in the hippocampus, oxidative stress and gliosis, and microarray analysis revealed a decline of genes associated with memory and cognition (Ze et al., 2014)