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A double-blind, randomized, placebo-controlled trial employing 227 adults with chronic kidney diseases were taking 25 mg, 75 mg, or 150 mg of bardoxolone methyl every day for a period of 24 weeks or 52 weeks
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Since these processes are believed to be partially responsible for the progressive neurological impairment after TBI, the development of effective therapeutic strategies capable of arresting secondary injury-induced damage has become a focus of intense research activity over the last two decades, both in clinical and preclinical settings

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Blood flow and hypoxia
