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37,38 Sympathetic signaling activates the hypothalamic-pituitary-adrenal (HPA) axis, a network that connects the nervous system to the adrenal glands and controls their release of the bodys primary stress hormone, cortisol

Montes-Curto P, Garca-Martnez M, Gmez-Martnez C, et al.Effectiveness of Three Types of Interventions in Patients with Fibromyalgiain a Region of Southern Catalonia

National Academy Press, 1989

Also, creatine is responsible for water retention on the skin which may lead to inflammation

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