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Additionally, paeonol, the main active component of Paeonia lactiflora Pall., suppresses the viability and metastasis of human lung cancer cells by up-regulating miR-126-5p expression, which subsequently downregulates its target gene ZEB2, a key EMT inducer that represses E-cadherin expression [328]

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Actions through IGFBP-3 MiR-19a-3p In a rat model of cerebral ischemia/reperfusion injury miR-19a-3p was found to promote reperfusion-induced inflammation and apoptosis by downregulating IGFBP-3implying a neuroprotective effect of IGFBP-3 [95]

BioMed Research International, 2015

References Masciullo, L

Antimelanogenic effects of luteolin 7-sulfate isolated from Phyllospadix iwatensis Makino