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This is a dual-action effect: it builds new collagen while simultaneously protecting existing collagen from degradation

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Mistreat it during reconstitution and it unfolds

Other disadvantages are related to evidence that the imidazoyl side chain groups of histidine can interfere with protein expression and folding and also mask the biological activity of the protein (Hearn and Acosta, 2001)

While some treatments may provide long-lasting results, others may require maintenance sessions to sustain the effects

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