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We investigated the efficacy and safety of oral vitamin B12 replacement for gastric cancer patients with vitamin B12 deficiency after total gastrectomy

Acrolein is increased in Alzheimers disease brain and is toxic to primary hippocampal cultures

A previous study demonstrated that seeds extract of nigella improved the maturation of oocytes isolated from PCOS mice by inhibiting the expression of COX-2 and oxidative stress (87)

Measurement of oxidized glutathione and reduced glutathione To measure GSH, 10L of saliva were incubated with 10L of a solution of ethanol o-phthaldehyde (OPT, 1mg/mL) and 180L of phosphate buffer (sodium phosphate 100mM, 2.5mM EDTA-Na2, pH 8.0) for 15min at room temperature

Key strategies include targeting lactate import with MCT inhibitors (for example, AZD3965), blocking NAD + recycling with NAMPT inhibitors (for example, FK866) or preventing the epigenetic programming with CBP/p300 inhibitors (for example, CCS1477 and FT-7051), several of which are already in clinical trials (Table 2)

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