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This is crucial context because it explains why AOD 9604 works better as part of a combination strategy rather than as a standalone fat loss solution

These results collectively indicate that Sirt1 is indispensable for NNMT-mediated regulation of glucose metabolism, and both NNMT and MNAM have the ability to upregulate Sirt1 expression

It helps preserve collagen through sirtuin activation, promotes autophagy in dermal fibroblasts, and enhances cellular responses to esthetic treatments