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showed that a DR5-targeting antibody-drug conjugate combined with a CDK inhibitor synergistically suppressed tumor growth in advanced CRC models, including chemotherapy-resistant settings

doi: 10.1016/j.bjp.2016.03.011 41

Likewise, direct depletion of cystine from plasma using an engineered cystine-degrading enzyme conjugate ( i.e., cyst(e)inase) arrests tumor growth and triggers cell death (Cramer et al., 2017)

Because the cochlea is so sensitive to changes in blood flow, ischemia during the reperfusion period might cause ROS to be produced [49]

A prudent approach may involve long-term dopaminergic upregulation during chronic opioid treatment with various pharmaceutical opioid analgesics

Aqueous extract of Sorindeia juglandifolia leaves protects methotrexate-induced liver and kidney damage in rat