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Functionalization of nanoparticles with targeting ligands, such as antibodies or peptides, allows for site-specific accumulation and cellular internalization of the peptide cargo

I already know that methyl is superior over cyano, because of its bioavailability and higher absorptive values
doi: 10.1186/1471-230X-12-170 111

The primary routes for permeation across the BBBinclude passive diffusion (lipid soluble solutes), ABC transporter efflux, carrier-mediated influx, and receptor-mediated transcytosis (Pandian et al., 2022
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

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