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Vpr (Viral protein R) localizes to mitochondria, where it induces membrane depolarization, increases ROS generation, and promotes mitochondrial mPTP opening

[2] Ghorbani Y, Schwenger KJP, Allard JP

Lastly, I want to talk a little bit about sustainability and traceability

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ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis

| | 5-Amino-1MQ Monotherapy | None | 50100mg daily | Daily oral or subcutaneous | NNMT inhibition preserves NAD+, activates AMPK and mitochondrial fat oxidation | 812 weeks | Promising preclinical data