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This phenomenon is thought to be due to the inability of cells to restore normal GSH levels or to increased production of reactive oxygen species (ROS), which can damage macromolecules fundamental to cell survival before being deactivated by antioxidant defenses

The two most notorious culprits are Proton Pump Inhibitors (PPIs) , used for acid reflux, and Metformin , the first-line treatment for Type 2 diabetes

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doi: 10.1016/j.fct.2018.09.079

Understanding dose-response curves prevents under-dosing (inadequate receptor engagement) and over-dosing (wasteful without additional benefit, potentially increasing side effects)

Tian, P., Zou, R., Wang, L., Chen, Y., Qian, X., and Zhao, J., J