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For OA, employing local intra-articular administration is expected to significantly reduce systemic exposure and related immune reactions, thus being considered a more realistic clinical translation pathway (Lin et al., 2024

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Organoselenium-catalysed reactions have been widely employed in a number of different reactions 16,17,18 , and substantial progress has been made by Breder 19,20,21 , Wirth 22,23,24 , Denmark 25,26 , Yeung 27 and Zhao 28,29,30,31 in recent years