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In consequence, lower levels of BH4 results in less generation of NO [63]

6 Current trends in clinical trials on IDD With the accelerating global aging process, clinical research on intervertebral disc degeneration (IDD) has shown significant growth

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Vitamin B12 plays a vital role in various bodily functions, keeping us energised and our body systems functioning properly

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Now if all of the methyl groups on methionine only went to make the bodys' creatine usage (1.3 gm per day), this might be sufficient, BUT, you use 2-3 times this amount of creatine, and production of creatine is only about 40% of all methylation, so you have to cycle methionine at least 5-10 times, so there has to be an extensive cycling of both folate and B12.This is assuming optimal function of SHMT (vitamin B6 dependent), MTHFR (vitamin B2/B3 dependent) and MTRR (vitamin B2/B3 dependent)