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Your dosage, drug form, and how often you take the drug will depend on: your age the condition being treated how severe your condition is other medical conditions you have how you react to the first dose Drug forms and strengths Generic: methotrexate Form: subcutaneous injection (vial) Strengths: 1 gm/40 mL (25 mg/mL) 50 mg/2 mL 100 mg/4 mL 200 mg/8 mL 250 mg/10 mL Brand: Otrexup Form: subcutaneous injection (auto-injector) Strengths: 10 mg/0.4 mL, 12.5 mg/0.4 mL, 15 mg/0.4 mL, 17.5 mg/0.4 mL, 20 mg/0.4 mL, 22.5 mg/0.4 mL, 25 mg/0.4 mL Brand: Rasuvo Form: subcutaneous injection (auto-injector) Strengths: 7.5 mg/0.15 mL, 10 mg/0.2 mL, 12.5 mg/0.25 mL, 15 mg/0.3 mL, 17.5 mg/0.35 mL, 20 mg/0.4 mL, 22.5 mg/0.45 mL, 25 mg/0.5 mL, 30 mg/0.6 mL Dosage for psoriasis Adult dosage (ages 1864 years) Typical starting dosage: 1025 mg once per week

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This results in elevated ROS, increased apoptosis, and impaired autophagy