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This further supports the application value of propolis in comprehensive H

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doi: 10.1681/ASN.2016030354 189

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FOXO4-DRI and ES2 peptides effectively disrupted the FOXO4-p53 interaction within the nucleus of senescent cells, leading to selective induction of apoptosis in these cells 25,34

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Subsequently, this therapy was tested in a patient with severe and refractory SLE who had not responded to other treatments (53)

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