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In vivo evaluation demonstrated that mice tolerated LAAM GSH-CQDs at doses up to 5000 mg kg 1 , compared to 18 mg kg 1 for LAAM TC-CQDs, 12 mg kg 1 for Lipo 2000, and 16 mg kg 1 for GO-CQDs

Early work in perfused rat heart preparations suggested that ergothioneine protected against ischemia-induced (oxidative) myocardial damage (83) , which was supported by later studies showing ergothioneine protects against reperfusion injury in rat liver (84) and intestinal (85) ischemic reperfusion models

Protection by pure and genistein fortified extra virgin olive oil, canola oil, and rice bran oil against acetic acid-induced ulcerative colitis in rats

Both in vitro and in vivo experiments confirmed that restoring levels of glutathione in PD patients represents a promising strategy to slow down the progression of the disease (Pradhan et al

Studies have found that Epitalon restored melatonin formation in the pineal body of older monkeys, increased superoxide dismutase (SOD) activity, and reduced the amount of LPO products, diene conjugates, and ROS [23, 33, 34]