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DIE lesions also exhibit increased SK1, S1P 3 and S1P 5 mRNA levels and the expression of a specific S1P transporter, Spns2, responsible for the extracellular release of S1P, is altered only in DIE, further highlighting the dysregulation of S1P signalling in the different forms of endometriosis [15] (Fig

While individual responses vary, established patterns from both research and community experience provide guidance

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Physicians may opt to treat these patients and monitor for improvement of metabolic markers, particularly in populations at high risk of clinical vitamin B 12 deficiency, or observe these patients and periodically reassess their levels of vitamin B 12 , homocysteine, and/or methylmalonic acid

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Balda MS, Gonzalez-Mariscal L, Matter K, Cereijido M, Anderson JM