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Influenza a virus protein PB1-F2 impairs innate immunity by inducing mitophagy

These effects are attributed to the reduction of glial activation, as well as the restoration of metabolite and neurotransmitter abnormalities

administered 100 mg/day for 4 weeks to athletes, and significant improvements were observed in biomarkers of muscle damage, antioxidant status, glutathione homeostasis, and without adverse effects [80]

2006;291:L1132L1141

In a series of important studies, it has been demonstrated that heme contributes to the pathogenesis of malaria by increasing tissue damage, while HO-1 and FTH contributes to disease tolerance irrespective of changes on pathogen loads (2124)

In both in vitro and in vivo models, PQ induces ferroptosis and iron overload by significantly increasing iron accumulation in the cytoplasm and mitochondria via the NCOA4-mediated ferritinophagy pathway