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ADCP ADCP is a rapid and potent mechanism of action for daratumumab across MM cells of differing CD38 expression [36]

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Triplicate experiments involving supercoiled pUC19 DNA exposed to increasing concentrations of Cu 3 -TC-Py in the presence of added reductant, sodium- L -ascorbate, were performed

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Lineage-tracing studies performed in vivo in transgenic mice with conditional Cre/Lox alleles have shown that Notch1 / and dominant negative Trp53 mutant ( Trp53 R245W ) mutant clones have a competitive advantage in normal mouse esophagus 33,37 , correlating with the screen results

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